Nogo-B impairs efferocytosis in monocyte-derived macrophages and exacerbates septic liver injury
Efferocytosis is compromised during sepsis, contributing to enhanced inflammation and organ damage. Our study identified Nogo-B as a critical mediator linking disrupted mitochondrial calcium uptake to impaired MDM efferocytosis. Targeting Nogo-B may represent a novel therapeutic strategy to restore efferocytosis and attenuate sepsis-related tissue injury. Further translational studies are needed to validate these findings in human disease.
Authors
- Yun Gao (ORCID: https://orcid.org/0000-0003-3530-7259)
- Dongming Wu
- Yuechen Wang (ORCID: https://orcid.org/0000-0002-8723-6205)
- Xiongxiong Pan
- Jian Xu (ORCID: https://orcid.org/0000-0002-6595-8602)
- Zhuqing Rao (ORCID: https://orcid.org/0000-0001-8551-0074)
- Weizhe Zhong
- Zhu Guan
- Xuehao Wang (ORCID: https://orcid.org/0000-0001-5849-0098)
- Ping Wang (ORCID: https://orcid.org/0000-0002-1557-0394)
- Yue Yu (ORCID: https://orcid.org/0000-0002-7620-6078)
- Ye Zhang (ORCID: https://orcid.org/0000-0002-6715-7884)
- Haoming Zhou (ORCID: https://orcid.org/0000-0003-2778-221X)
- Haoran Hu (ORCID: https://orcid.org/0009-0006-4080-6887)
- Yan Bai
- Fei Li (ORCID: https://orcid.org/0009-0008-1125-175X)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Jiangsu Province Hospital (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101556
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00