Study of the Bioavailability of Methyluracil <i>in Vitro</i> and Its Biocompatibility <i>in Vivo</i> in the Composition of Polyurethane Implant Material

The development of polymer implant materials for use as drug carriers is an urgent task today. The aim of this work was to study the bioavailability of methyluracil when immobilized on a polyurethane carrier in vitro, as well as to study the biocompatibility of the obtained material when conducting model operations on experimental animals in vivo. As a result of the conducted studies, it was shown that the bioavailability of methyluracil immobilized on a polyurethane carrier is 78.5%, its prolonged release into the model environment is observed for 84 days. At the same time, more than 50% of the injected methyluracil was released by the 14th day of the study, which can significantly contribute to increasing the efficiency of regenerative processes at the implantation site, especially in the initial stages of the postoperative period. The conducted model operations on experimental animals made it possible to establish that the developed composite material with methyluracil is biocompatible and bioactive. Implantation of polymer samples with prolonged release of methyluracil contributed to the reduction of alteration and exudation phenomena in the implant placement area, activation of regeneration processes, and the formation of a mature and thin capsule around the implant already in the early stages of the study.