A high stroma-tumor ratio is associated with an immunosuppressive tumor microenvironment and a poor prognosis in bladder cancer
A high stromal content shapes a more immunosuppressive tumor microenvironment and can predict not only the immune phenotypes but also the clinical phenotypes in BLCA. A high stromal content predicts a worse prognosis. STR exhibits great potential as a biomarker for evaluating the immunogenicity of BLCA and its likelihood of responding to immunotherapy.
Authors
- Yichao Zhu (ORCID: https://orcid.org/0000-0003-3499-8510)
- Yu Liu (ORCID: https://orcid.org/0000-0002-7968-0162)
- Z. Q. Zhu (ORCID: https://orcid.org/0000-0001-7175-3307)
- Zirong Lu
- H.C. Tai
- Yurong Da
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fonc.2025.1604609
- Citations
- 1
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01