Expressed mutated genes in Sezary syndrome and their potential prognostic value in patients treated with extracorporeal photopheresis
This is the first evaluation in SS of expressed mutations in a large panel of CTCL-driver genes. Also innovative is the monitoring of mutated genes in patients' malignant lymphocytes during ECP, a first-line treatment of CTCL, which highlights novel candidates associated with ECP resistance that might unmask novel pharmacological vulnerabilities to be exploited during ECP for a personalized treatment.
Authors
- Cristina Cristofoletti (ORCID: https://orcid.org/0000-0003-3886-2485)
- Cristian Bassi (ORCID: https://orcid.org/0000-0002-5823-709X)
- Maria Pilla (ORCID: https://orcid.org/0000-0001-8757-3669)
- Alessandra Frezzolini
- Martina Fioretti (ORCID: https://orcid.org/0000-0002-6606-706X)
- Alessandro Monopoli (ORCID: https://orcid.org/0000-0002-9509-1405)
- Cosimo Di Raimondo (ORCID: https://orcid.org/0000-0003-4691-9381)
- Luca Mazzarella (ORCID: https://orcid.org/0000-0002-4043-3279)
- Gianmaria Frigè (ORCID: https://orcid.org/0000-0003-3253-7091)
- Ylenia Aura Minafò (ORCID: https://orcid.org/0000-0002-3818-2837)
- Giandomenico Russo (ORCID: https://orcid.org/0000-0002-7718-9687)
- Giulia Salvatore (ORCID: https://orcid.org/0000-0003-3573-9254)
- Stefania D’Atri (ORCID: https://orcid.org/0000-0001-9852-7377)
- Maria Grazia Narducci (ORCID: https://orcid.org/0000-0002-8877-4611)
- Enrico Scala (ORCID: https://orcid.org/0000-0002-9391-9168)
- Maria Pina Accetturi (ORCID: https://orcid.org/0000-0003-1682-8286)
- Massimo Negrini (ORCID: https://orcid.org/0000-0002-0007-1920)
- Giovanni Luca Scaglione (ORCID: https://orcid.org/0000-0001-5622-7843)
Institutions
- University of Ferrara (IT)
- Istituto Dermopatico dell'Immacolata (IT)
- Policlinico Tor Vergata (IT)
- European Institute of Oncology (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fimmu.2025.1589467
- Citations
- 1
- Primary Topic
- Cutaneous lymphoproliferative disorders research
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- Ministero della Salute