Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

The imbalance between Th17 and T-regulatory immune responses is present not only at cytokine level but also at a cellular level in MASLD. Especially in advanced disease, a higher percentage of IL-17 producing T-cells is coupled with the lower number of T-regulatory cells.

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Publication Details

Journal
Frontiers in Immunology
Published
2025-08-22
DOI
https://doi.org/10.3389/fimmu.2025.1597204
Primary Topic
Liver Disease Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

Magdalena Świderska, Elżbieta Supruniuk, Kamil Grubczak, Marcin Moniuszko et al.
Frontiers in Immunology
Liver Disease Diagnosis and Treatment
article

Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease

Magdalena Świderska, Elżbieta Supruniuk, Kamil Grubczak, Marcin Moniuszko, Adrian Chabowski, Jerzy Jaroszewicz, Anna Parfieniuk‐Kowerda, Robert Flisiak
article en

Abstract

The imbalance between Th17 and T-regulatory immune responses is present not only at cytokine level but also at a cellular level in MASLD. Especially in advanced disease, a higher percentage of IL-17 producing T-cells is coupled with the lower number of T-regulatory cells.

Frontiers in ImmunologyVol. 16
Medical University of Białystok (PL), Medical University of Silesia (PL), Edward F. Szczepanik State School of Higher Professional Education in Suwalki (PL)
Narodowe Centrum Nauki, Uniwersytet Medyczny w Białymstoku
Openalex Percentile: Top 70%
Liver Disease Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Increased frequencies of human Th-17 CD4+ T-cells and decreased T-regulatory cells in patients with early and advanced metabolic dysfunction-associated steatotic liver disease — Magdalena Świderska, Elżbieta Supruniuk, et al. · Frontiers in Immunology (2025) | TGRS Research Map | TGRS