Moderating role of triglycerides in the relationship between amyloid-β, hippocampal atrophy, and cognitive decline in mild cognitive impairment and early Alzheimer’s disease
These findings highlight hippocampal atrophy as a key pathway linking Aβ burden to cognitive impairment. Moreover, higher triglyceride levels may exacerbate Aβ-related neurodegeneration in individuals with MCI and early-stage ADD. Metabolic risk factors, such as triglycerides, may play an important role in strategies to prevent or delay cognitive decline in older adults with MCI and early ADD.
Authors
- Soonjo Hwang (ORCID: https://orcid.org/0000-0001-5117-2468)
- Ji‐Woo Seok (ORCID: https://orcid.org/0000-0001-5690-2802)
- Kun Ho Lee (ORCID: https://orcid.org/0000-0003-4144-8162)
- Kahye Kim
- Jaeuk U. Kim (ORCID: https://orcid.org/0000-0003-0408-5569)
Institutions
- Chosun University (KR)
- Korea Institute of Oriental Medicine (KR)
- Korea Brain Research Institute (KR)
- University of Nebraska Medical Center (US)
- Gwangju University (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fnagi.2025.1592341
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Korea Brain Research Institute
- Korea Institute of Oriental Medicine
- National Research Council of Science and Technology
- Ministry of Science and ICT, South Korea