Cu2+/Cu+ redox-cycling-driven dual-mode sensor for simultaneous monitoring of acetylcholinesterase activity and pesticide exposure
This study developed a portable detection platform based on valence interconversion coupled enzyme inhibition with probe responsiveness. The dual-signal output enhanced reliability and the redox-driven mechanism enabled signal amplification. This advancement provided a real-time, portable and rapid detection for AChE activity and pesticide exposure of TCMs, bridging gaps in agricultural safety and pharmaceutical standardization.
Authors
- Yongqing Wu (ORCID: https://orcid.org/0000-0001-9581-6966)
- Bing Wang (ORCID: https://orcid.org/0000-0002-2773-2370)
- Yuanyuan Ge (ORCID: https://orcid.org/0000-0001-6531-640X)
- Guojing Liu
- Kunhui Sun
- Xiaolei Wu (ORCID: https://orcid.org/0000-0001-8270-7621)
- Xie‐an Yu (ORCID: https://orcid.org/0000-0003-2918-7369)
- Ping Wang (ORCID: https://orcid.org/0000-0001-6474-2722)
- Han Zhang (ORCID: https://orcid.org/0000-0002-4237-8701)
- Shuhong Wang (ORCID: https://orcid.org/0000-0002-5251-8704)
- Xiaoyi Liu (ORCID: https://orcid.org/0009-0006-5862-2031)
- Ziyu Guo
- Lina Zeng (ORCID: https://orcid.org/0000-0001-6717-9285)
- Sitong Lai
- Yiqi Yan
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Tsumura Research Institute (Japan) (JP)
- Jiang Xi Institute for Drug Control (CN)
- Shenzhen Institute for Drug Control (CN)
- Jiangmen Polytechnic (CN)
- Tianjin haihe hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fphar.2025.1640821
- Primary Topic
- Molecular Sensors and Ion Detection
- Type
- article
- Field-Weighted Citation Impact
- 0.00