The distinct effects of metformin and imeglimin on high glucose-induced alterations in metabolic function and reactive oxygen species production in mouse Schwann cells are modulated by pemafibrate and/or fatty acid-binding proteins.
Imeglimin exerted beneficial biological effects by enhancing the energetic state and reducing ROS production without inducing metabolic quiescence in high glucose-treated SCs. These findings suggest that Ime has therapeutic potential for DPN, although its effects may be modulated by intracellular lipid metabolism.
Authors
- Megumi Higashide (ORCID: https://orcid.org/0009-0007-0534-0257)
- Tatsuya Sato (ORCID: https://orcid.org/0000-0001-7876-1772)
- Nami Nishikiori (ORCID: https://orcid.org/0009-0001-9894-8523)
- Megumi Watanabe (ORCID: https://orcid.org/0000-0002-8026-6532)
- Toshifumi Ogawa
- Hiroshi Ohguro
Institutions
- Sapporo Medical University (JP)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fncel.2025.1634262
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Japan Society for the Promotion of Science