Microbial diversity and composition in the gut microbiome of patients during systemic inflammatory response syndrome: can we use gut bacteria as potential biomarkers to characterize sepsis?
Sepsis and non-sepsis patients showed distinct gut microbiota profiles in early AT. In sepsis, the loss of taxa involved in key metabolic functions, as short-chain fatty acid production, reflects dysbiosis and may contribute to worse outcomes. Prolonged antibiotic use may favor enteropathogen overgrowth and gut translocation. These findings highlight the potential of microbiota-based strategies to guide antimicrobial therapy and improve clinical outcomes in critically ill patients.
Authors
- Miriane Melo Silveira Moretti (ORCID: https://orcid.org/0000-0002-5365-5997)
- Diego R. Falci (ORCID: https://orcid.org/0000-0002-8683-3833)
- Rafaela Ramalho Guerra (ORCID: https://orcid.org/0000-0003-0223-6423)
- Patricia Orlandi Barth (ORCID: https://orcid.org/0000-0003-0763-1430)
- Luciana Giordani (ORCID: https://orcid.org/0000-0003-2626-0452)
- Márcio Manozzo Boniatti (ORCID: https://orcid.org/0000-0001-9921-0785)
- Laila Almeida Viana (ORCID: https://orcid.org/0000-0002-5064-9735)
- Gyselle Ribeiro de Carvalho Oliveira (ORCID: https://orcid.org/0000-0001-8940-7111)
- Patrícia da Silva Fernandes (ORCID: https://orcid.org/0009-0001-4350-5709)
- Dariane Castro Pereira (ORCID: https://orcid.org/0000-0002-9119-6242)
- Afonso Luís Barth (ORCID: https://orcid.org/0000-0002-7969-3908)
- Otávio von Ameln Lovison (ORCID: https://orcid.org/0000-0003-0950-1656)
- Giovanna de Ross Forni
- Tarsila Vieceli (ORCID: https://orcid.org/0000-0001-6274-1320)
- Fabiana Caroline Zempulski Volpato (ORCID: https://orcid.org/0000-0002-5225-2256)
- William Latosinski Matos
- Andreza Francisco Martins (ORCID: https://orcid.org/0000-0001-6227-1920)
Institutions
- Universidade Federal do Rio Grande do Sul (BR)
- Hospital de Clínicas de Porto Alegre (BR)
- Universidade Federal do Paraná (BR)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fcimb.2025.1622866
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Instituto Nacional de Pesquisas em Resistência a Antimicrobianos
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Hospital de Clínicas de Porto Alegre
- Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
- Fundação Instituto de Pesquisas Econômicas