Regulation of EMT-MET and chemoresistance by the Lc3Cer-synthase B3GNT5
B3GNT5 is frequently altered in human cancers and correlates with adverse clinical outcomes. Functional depletion reveals its key role in regulating glycosphingolipid metabolism, signaling, and malignant phenotypes. These findings support B3GNT5 as an important target for therapeutic intervention in cancer.
Authors
- Katherine Hylton Rorie
- Santiago Lima (ORCID: https://orcid.org/0000-0002-6949-7962)
- AMANDA J.G. DICKINSON (ORCID: https://orcid.org/0000-0002-1427-9140)
- Laura E. Clark
Institutions
- Virginia Commonwealth University (US)
- Virginia Cancer Institute (US)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s12885-025-14717-5
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Virginia Commonwealth University
- National Institutes of Health
- National Cancer Institute