The role of glycerophospholipid metabolism in feline parvovirus infected CRFK cells
FPV infection promotes replication by reprogramming host cell glycerophospholipid metabolism. The PCYT2-mediated PE/PC synthesis pathway and the PLPP1 or LPIN3 regulated diacylglycerol (DG) generation pathway play central roles. This finding highlights the pivotal role of glycerophospholipid metabolism during FPV infection, offering insights into antiviral strategies targeting this pathway.
Authors
- Zhen Sun (ORCID: https://orcid.org/0000-0002-2991-9999)
- Jiayu Yu (ORCID: https://orcid.org/0000-0003-0685-4763)
- Hongwei Zhu (ORCID: https://orcid.org/0000-0001-5520-3321)
- Jianlong Zhang (ORCID: https://orcid.org/0000-0002-8918-5771)
- Xin Yu (ORCID: https://orcid.org/0000-0002-1122-0899)
- Linlin Jiang (ORCID: https://orcid.org/0000-0002-5250-9170)
- Yang Liu (ORCID: https://orcid.org/0000-0002-9937-5958)
- Xingxiao Zhang
Institutions
- Ludong University (CN)
- Yantai University (CN)
- Yantai Academy of Agricultural Sciences (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fmicb.2025.1658838
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 0.00