KRAS Mutations in Colorectal Adenocarcinoma: Incidence and Association with Histological Features with Particular Reference to Gly12Asp in a Multicenter GIPAD Real-World Study
Recent data have pinpointed the prognostic and predictive value of <i>Gly12Asp</i> mutation, and our results contribute to understanding its biology, with particular focus on peculiar clinicopathological features. Moreover, we found significant differences in pathology reports and assays for molecular profiling in different centers, which can affect a standardized therapeutic approach in CRC.
Authors
- Paola Parrella (ORCID: https://orcid.org/0000-0001-6031-9636)
- Barbara Pasculli (ORCID: https://orcid.org/0000-0002-3333-0255)
- Maria Raffaella Ambrosio (ORCID: https://orcid.org/0000-0002-1172-6902)
- Federica Grillo (ORCID: https://orcid.org/0000-0001-6477-3182)
- Valentina Angerilli (ORCID: https://orcid.org/0000-0002-9799-9257)
- Alessandro Vanoli (ORCID: https://orcid.org/0000-0002-2976-7032)
- Laura Gandolfi (ORCID: https://orcid.org/0000-0003-1018-1290)
- Paola Parente (ORCID: https://orcid.org/0000-0003-0591-6723)
- F Adotti (ORCID: https://orcid.org/0000-0002-9233-298X)
- Stefania Scarpino (ORCID: https://orcid.org/0009-0009-9668-9626)
- Federica Petrelli (ORCID: https://orcid.org/0000-0002-7352-6770)
- Giovanni Lanza (ORCID: https://orcid.org/0000-0002-5362-1236)
- Laura Melocchi (ORCID: https://orcid.org/0000-0001-5161-6305)
- Roberta Gafà (ORCID: https://orcid.org/0000-0002-3271-2198)
- Matteo Fassan (ORCID: https://orcid.org/0000-0001-6515-5482)
- Jessica Gasparello (ORCID: https://orcid.org/0000-0001-8557-0739)
- Luca Mastracci (ORCID: https://orcid.org/0000-0003-0193-5281)
- Maria Cristina Macciomei (ORCID: https://orcid.org/0000-0002-4199-5636)
- Francesco Vasuri (ORCID: https://orcid.org/0000-0002-1145-6025)
- Luca Saragoni (ORCID: https://orcid.org/0000-0002-2137-9596)
- Maria Laura Giobbe
- Alessandro Caputo (ORCID: https://orcid.org/0000-0001-5139-3869)
- Francesca Antoci
- Emanuela Pilozzi (ORCID: https://orcid.org/0000-0002-7110-9172)
- Andrea Ascione (ORCID: https://orcid.org/0000-0002-4253-3193)
- Norman Veccia
Institutions
- University of Salerno (IT)
- University of Padua (IT)
- University of Ferrara (IT)
- University of Pavia (IT)
- Casa Sollievo della Sofferenza (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Azienda Ospedaliera San Camillo-Forlanini (IT)
- AULSS 2 Marca Trevigiana (IT)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliera Sant'Andrea (IT)
- Arcispedale Sant'Anna (IT)
- Ospedale Annunziata di Cosenza (IT)
- Ospedale Policlinico San Martino (IT)
- Fondazione Poliambulanza Istituto Ospedaliero (IT)
- Policlinico San Matteo Fondazione (IT)
- Azienda Usl Toscana Centro (IT)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3390/cancers17172721
- Citations
- 1
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Sapienza Università di Roma