Transcriptomics assisted by metabolomics analysis provides insights into regulation mechanisms during carcinogenic process in a hydrodynamically transfected liver cancer model
In a hydrodynamic transfection-based mouse model of HCC, female mice showed higher tumor incidence, faster tumor growth, and more severe disease compared to male mice. This sex-based difference may be associated with lower hepatic expression of glutathione S-transferases (GSTs) in females. Targeting GST expression or activity may offer a potential strategy for sex-informed approaches to HCC prevention and therapy.
Authors
- Zhouxiang Liao (ORCID: https://orcid.org/0000-0003-1295-2917)
- Qi Zhang (ORCID: https://orcid.org/0009-0005-1853-6529)
- Xuejing Huang (ORCID: https://orcid.org/0009-0003-2917-8240)
- Min He (ORCID: https://orcid.org/0000-0002-2735-2474)
- Sha Wen
- Yongfeng Li (ORCID: https://orcid.org/0000-0002-7949-5709)
- Xiaojing Cheng (ORCID: https://orcid.org/0009-0003-4431-8408)
- Lichao Yang (ORCID: https://orcid.org/0000-0003-3096-9632)
- Zhenyu Song (ORCID: https://orcid.org/0009-0001-1196-8952)
Institutions
- Guangxi University (CN)
- Guangxi Medical University (CN)
- Guangxi Center for Disease Prevention and Control (CN)
- Tumor Hospital of Guangxi Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s12935-025-03937-1
- Citations
- 1
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Natural Science Foundation of Guangxi Zhuang Autonomous Region