Hua-Zhuo-Ning-Fu Decoction Ameliorates Psoriasis by Inhibiting TNF-Α/IL-6 and PI3K/AKT Signaling Pathway: A Network PharmacologyApproach and Experimental Validation
In summary, HZD potentially mitigated inflammatory responses by targeting the TNF-α and IL-6 proteins, interfered with the PI3K/AKT pathway, and consequently drove the anti-psoriatic effect in IMQ-induced mice. Our findings provide a theoretical basis for HZD's clinical use in psoriasis treatment.
Authors
- Zhuzhu Wu
- Shuai Man (ORCID: https://orcid.org/0000-0002-7525-7092)
- Zhaoyizhu Guan (ORCID: https://orcid.org/0009-0000-3693-1577)
- Zhenguo Wang (ORCID: https://orcid.org/0000-0001-7105-4071)
- Mengxue Han
- Wenke Ma
Institutions
- Macau University of Science and Technology (MO)
- Shandong University of Traditional Chinese Medicine (CN)
- University of Macau (MO)
Publication Details
- Journal
- Combinatorial Chemistry & High Throughput Screening
- Published
- 2025-08-15
- DOI
- https://doi.org/10.2174/0113862073390038250723201614
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.00