An Intriguing Case Report of Type 2 AutoimmunePolyendocrine Syndrome Post-SARS-CoV-2: Causeor Coincidence?

This case adds to limited evidence suggesting a possible link between SARS-CoV-2 infection and the onset or unmasking of APS-2. While a direct causal role of the virus remains uncertain, SARS-CoV-2 may function as an environmental trigger, accelerating the transition from subclinical to clinical autoimmunity in genetically susceptible patients. This observation supports the need for clinical vigilance in post-COVID-19 patients presenting with nonspecific but suggestive endocrine symptoms.

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Publication Details

Journal
Endocrine Metabolic & Immune Disorders - Drug Targets
Published
2025-08-18
DOI
https://doi.org/10.2174/0118715303407830250807114958
Primary Topic
Adrenal Hormones and Disorders
Type
article
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article

An Intriguing Case Report of Type 2 AutoimmunePolyendocrine Syndrome Post-SARS-CoV-2: Causeor Coincidence?

Caterina Mian, C. Betterle, Marianna Torchio, Giacomo Voltan et al.
Endocrine Metabolic & Immune Disorders - Drug Targets
Adrenal Hormones and Disorders
article

An Intriguing Case Report of Type 2 AutoimmunePolyendocrine Syndrome Post-SARS-CoV-2: Causeor Coincidence?

Caterina Mian, C. Betterle, Marianna Torchio, Giacomo Voltan, Chiara Sabbadin, Andrea Graziani
article en

Abstract

This case adds to limited evidence suggesting a possible link between SARS-CoV-2 infection and the onset or unmasking of APS-2. While a direct causal role of the virus remains uncertain, SARS-CoV-2 may function as an environmental trigger, accelerating the transition from subclinical to clinical autoimmunity in genetically susceptible patients. This observation supports the need for clinical vigilance in post-COVID-19 patients presenting with nonspecific but suggestive endocrine symptoms.

Endocrine Metabolic & Immune Disorders - Drug TargetsVol. 25
University of Padua (IT)
Openalex Percentile: Top 70%
Adrenal Hormones and Disorders
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