Clozapine Dose Reduction in Remitted Patients With Treatment-Resistant Schizophrenia: A Case Series
Reducing the clozapine maintenance dose in remitted TRS patients carried a substantial risk of relapse. The risk may be lower when dose reductions are guided by clozapine levels and implemented gradually over several months to years. Larger samples are needed to identify predictors of relapse in TRS patients undergoing clozapine deprescribing.
Authors
- Ashok Kumar (ORCID: https://orcid.org/0000-0002-4299-626X)
- Gary Remington
- Sacha Agrawal (ORCID: https://orcid.org/0000-0002-2007-7289)
- Sri Mahavir Agarwal (ORCID: https://orcid.org/0000-0002-2705-5146)
- Mohammed Alarabi (ORCID: https://orcid.org/0000-0001-5439-6109)
- Leah Burton
- Valerie Powell
- Tanner Isinger
Institutions
- Centre for Addiction and Mental Health (CA)
- University of Toronto (CA)
- Scarborough Health Network (CA)
- King Saud University (SA)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1093/schbul/sbaf139
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00