Feasibility and efficacy of vascular closure device for sealing uterine entry site: preliminary results from pregnant sheep model
Employing multiple orthogonal approaches, we have shown for the first time that the Perclose device is both feasible and potentially efficacious as a novel means of uterine port closure in our preclinical sheep model of fetoscopic surgery. Inspired by our success in this preclinical model, we anticipate that clinical validation studies will provide translational data and a direct means of measuring efficacy in the reduction of CAS, PPROM and preterm birth. © 2025 International Society of Ultrasound in Obstetrics and Gynecology.
Authors
- Ramen H. Chmait (ORCID: https://orcid.org/0000-0002-4202-0259)
- Chrystalle Katte Carreon (ORCID: https://orcid.org/0000-0003-2152-7998)
- Eyal Krispin (ORCID: https://orcid.org/0000-0001-5859-9528)
- José L. Peiró (ORCID: https://orcid.org/0000-0002-2272-1381)
- Kjersti Marie Aagaard (ORCID: https://orcid.org/0000-0002-2960-0371)
- Y. Ville (ORCID: https://orcid.org/0000-0002-5675-267X)
- Alireza Abdollah Shamshirsaz (ORCID: https://orcid.org/0000-0001-6333-3177)
- Nikan Zargarzadeh (ORCID: https://orcid.org/0000-0002-1415-2086)
- Ali Javinani (ORCID: https://orcid.org/0000-0003-4056-1585)
- Seyed M. Qaderi (ORCID: https://orcid.org/0000-0001-7595-7833)
- Braxton Forde
Institutions
- University of Southern California (US)
- Cincinnati Children's Hospital Medical Center (US)
- Hôpital Necker-Enfants Malades (FR)
- Boston Children's Hospital (US)
- Harvard University (US)
- HCA Healthcare (US)
- Society for Maternal-Fetal Medicine (US)
- Institut Necker Enfants Malades (FR)
Publication Details
- Journal
- Ultrasound in Obstetrics and Gynecology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1002/uog.70012
- Primary Topic
- Maternal and Perinatal Health Interventions
- Type
- article
- Field-Weighted Citation Impact
- 0.00