Pure platelet-rich plasma delays intervertebral disc degeneration by activating SIRT1-mediated autophagy in nucleus pulposus cells
P-PRP protected against degenerative NPCs by activating functional autophagic flux and restoring mitochondrial function via the SIRT1 signaling axis. These findings provide novel mechanistic insight into PRP-based therapies and identify SIRT1 as a promising target for the treatment of IVDD.
Authors
- Zhili Ding (ORCID: https://orcid.org/0000-0002-7161-5649)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-8811-5552)
- Yu Ding (ORCID: https://orcid.org/0000-0003-1783-5461)
- Jiaheng Han
- Jie Huang
Institutions
- Anhui Medical University (CN)
- Peking University (CN)
- Chinese PLA General Hospital (CN)
- Peking University People's Hospital (CN)
- South China University of Technology (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s13018-025-06205-0
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- National Natural Science Foundation of China