Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition
Our findings highlight the potent bone-healing effects of Scl-ab and its potential as an adjuvant to anti-cancer therapy, offering a promising approach to improve clinical outcomes and the quality of life for MM patients.
Authors
- Hayley M. Sabol (ORCID: https://orcid.org/0000-0003-2498-9258)
- Intawat Nookaew (ORCID: https://orcid.org/0000-0001-8901-1088)
- Alison J. Frontier (ORCID: https://orcid.org/0000-0001-5560-7414)
- Jillian Hackney
- Japneet Kaur (ORCID: https://orcid.org/0000-0001-9624-017X)
- Elena Ambrogini (ORCID: https://orcid.org/0000-0002-5704-6072)
- C. Lowry Barnes (ORCID: https://orcid.org/0000-0003-3776-5384)
- Cecile Bustamante-Gomez (ORCID: https://orcid.org/0009-0004-6176-700X)
- Carolina Schinke (ORCID: https://orcid.org/0000-0002-2699-1741)
- Aric Anloague
- Frank H. Ebetino (ORCID: https://orcid.org/0000-0002-9133-1360)
- Matthew T. Drake (ORCID: https://orcid.org/0000-0002-3662-7345)
- Jeffrey B. Stambough (ORCID: https://orcid.org/0000-0003-0950-5227)
- Jesús Delgado‐Calle (ORCID: https://orcid.org/0000-0002-2083-2774)
- Christopher P. Wardell (ORCID: https://orcid.org/0000-0002-9416-7818)
- Dan C. Mann (ORCID: https://orcid.org/0000-0002-6260-8615)
- Maurizio Zangari (ORCID: https://orcid.org/0000-0002-1720-3854)
- Frits van Rhee (ORCID: https://orcid.org/0000-0001-9959-1282)
- Marta Diaz‐delCastillo (ORCID: https://orcid.org/0000-0001-7719-6839)
- Bethany C. Paxton
- Sharmin Khan
- Syed Naqvi (ORCID: https://orcid.org/0009-0007-5533-500X)
- Mattie R Nester
Institutions
- Pasadena City College (US)
- Aarhus University (DK)
- Central Arkansas Veterans Healthcare System (US)
- Mayo Clinic in Arizona (US)
- Winthrop Rockefeller Foundation (US)
- University of Rochester (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Experimental Hematology and Oncology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s40164-025-00699-4
- Citations
- 1
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- Aarhus Universitet
- Aase og Ejnar Danielsens Fond
- Odense Universitetshospital
- National Institutes of Health
- National Institute of General Medical Sciences