Neuroprotective Potential of Jimson Weed in Methotrexate-Induced Neurotoxicity: Insights into Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Mechanisms via Modulation of Caspase-3, Interleukin-6, and Tumor Necrosis Factor-Alpha: In Silico
Co-treatment of ELEJW with MXT overturned the oxidative stress, inflammation, and histological alterations perpetuated by MXT. Therefore, Jimson weed should be explored as a supportive therapy for the management of MXT-induced neurological derangements.
Authors
- Periyasamy Vijayalakshmi
- Mansour K. Gatasheh (ORCID: https://orcid.org/0000-0002-0101-1014)
- Ademola C. Famurewa (ORCID: https://orcid.org/0000-0002-8795-9964)
- Esther Ugo Alum (ORCID: https://orcid.org/0000-0003-4105-8615)
- Daniel Ejim Uti (ORCID: https://orcid.org/0000-0002-1129-1785)
- Rajapandiyan Krishnamoorthy
- Shanthi Subbarayan
Institutions
- Funai Electric (Japan) (JP)
- Benue State University (NG)
- Kampala International University (UG)
- King Saud University (SA)
- Federal Medical Centre (NG)
- Holy Cross College (US)
- Holy Cross College (GB)
- Alex Ekwueme Federal University, Ndufu-Alike
Publication Details
- Journal
- Endocrine Metabolic & Immune Disorders - Drug Targets
- Published
- 2025-08-15
- DOI
- https://doi.org/10.2174/0118715303350736241220090850
- Primary Topic
- Acute Lymphoblastic Leukemia research
- Type
- article
- Field-Weighted Citation Impact
- 0.00