Long-term impact of growth hormone therapy on mortality and type 2 diabetes in Prader–Willi syndrome: a nationwide cohort study
GHT was not a direct predictor of mortality in PWS, which was instead influenced by comorbidities. However, its prolonged use was linked to increased T2DM. These findings support individualized risk assessment and metabolic monitoring in patients with PWS receiving GHT.
Authors
- Aram Yang (ORCID: https://orcid.org/0000-0003-4731-3701)
- Yong Jun Choi (ORCID: https://orcid.org/0000-0003-3960-8470)
Institutions
- Kangbuk Samsung Hospital (KR)
- Gangnam Severance Hospital (KR)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fendo.2025.1642129
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Health Insurance Service