ADSC-EVs Activate Autophagy Via the AKT/FOXO1 Pathway to Inhibit Tendon Fibrosis
Our findings confirm that ADSC-EVs can reduce fibrosis and inflammation during tendon healing, which may be a promising treatment approach to improve the quality of tendon healing. Therefore, ADSC-EVs have the potential to be used as cell-free biotherapeutics.
Authors
- Bo Xu (ORCID: https://orcid.org/0000-0002-6443-6298)
- Zhaozhu Li (ORCID: https://orcid.org/0000-0002-8953-8186)
- Zhitao Jiang (ORCID: https://orcid.org/0000-0003-0537-0548)
- Hengchen Liu (ORCID: https://orcid.org/0000-0001-7263-6735)
- Tingting Zhang (ORCID: https://orcid.org/0000-0002-4584-9900)
- Rui Li (ORCID: https://orcid.org/0000-0003-1318-0998)
- Yang Wu (ORCID: https://orcid.org/0000-0002-1065-939X)
- Xiangqi Li (ORCID: https://orcid.org/0000-0002-9618-8567)
- Yujun Guo
- Aodan Zhang
Institutions
- Harbin Medical University (CN)
- Xiamen University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
Publication Details
- Journal
- The American Journal of Sports Medicine
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1177/03635465251358465
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00