Diurnal rhythm of the human plasma proteome
These findings demonstrate that over one-quarter of the human plasma proteome is under diurnal control. Such oscillations might have direct clinical implications, as the time-of-day may alter biomarker accuracy. Incorporating diurnal timing into diagnostic and research protocols, through standardized sampling or time-sensitive reference intervals, could improve patient care and inform future biomarker discoveries. Further research in larger, more diverse populations is needed to generalize these results and streamline practices in a way that takes diurnal variation into account.
Authors
- Jens Hannibal (ORCID: https://orcid.org/0000-0001-9416-0125)
- Henrik L. Jørgensen (ORCID: https://orcid.org/0000-0001-6374-761X)
- Annelaura Bach Nielsen (ORCID: https://orcid.org/0009-0005-2855-208X)
- Henriette P. Sennels (ORCID: https://orcid.org/0000-0002-4866-1807)
- Nicolai J. Wewer Albrechtsen (ORCID: https://orcid.org/0000-0003-4230-5753)
- Ching‐Yan Chloé Yeung (ORCID: https://orcid.org/0000-0002-7076-8109)
- Gabriela Pruś (ORCID: https://orcid.org/0000-0001-6003-6708)
- Christine Rasmussen
- Elvar M. S. Jóhönnuson
Institutions
- University of Copenhagen (DK)
- Frederiksberg Hospital (DK)
- Bispebjerg Hospital (DK)
- Hvidovre Hospital (DK)
- Copenhagen University Hospital (DK)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s12014-025-09551-7
- Citations
- 2
- Primary Topic
- Advanced Proteomics Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 1.51
Funders
- Københavns Universitet
- Novo Nordisk
- Faculty of Health and Medical Sciences, University of Western Australia
- Det Sundhedsvidenskabelige Fakultet, Københavns Universitet