Role of Simvastatin in Enhancing Bone Regeneration in Posterior Maxilla: A Comparative Study

Background and Objectives The present study is done to evaluate the “Role of Simvastatin in Enhancing Bone Regeneration in Posterior Maxilla.” Method Sample size was determined to be 30 patients. Patients who required extractions at contralateral sites in the posterior maxilla were included in the study. Simvastatin graft was placed in one socket called the study socket and secured with gel-foam, and the control socket on the opposite side was allowed to heal without any intervention. Routine hematological investigations were done for the patient before extractions. Informed consent was taken. Radiographic follow-up was planned after extractions post-operatively 1 week, 4 weeks, and 12 weeks. Parameters used for comparison were pain, swelling, and bone density measurements. Results Scores for bone density were assessed radiographically, which were significantly higher on the study site than the control site. No significant difference was noticed between pain and swelling scores between study and control sockets. Conclusion Simvastatin graft use as a socket preservation material turned out to be on the positive side, as its application as a graft produced significant results in enhanced bone regeneration in the posterior maxilla, with extra added benefits of cost-effectiveness and complete eradication of donor-site morbidity.