Inhibition of Extracellular Matrix Protein Fibulin-3 Reduces Immunosuppressive Signaling and Increases Macrophage Activation in Glioblastoma
Inhibition of the ECM protein fibulin-3, which is highly upregulated in glioblastoma tumors, decreases immunosuppressive signals produced by the tumor cells and exposes them to increased attack by TAMs.
Authors
- Arivazhagan Roshini (ORCID: https://orcid.org/0009-0001-9842-3508)
- Harish Babu (ORCID: https://orcid.org/0000-0001-8985-7526)
- Somanath Kundu (ORCID: https://orcid.org/0000-0003-0412-5065)
- Mariano S. Viapiano (ORCID: https://orcid.org/0000-0002-8756-388X)
- Abigail G. Venskus (ORCID: https://orcid.org/0009-0009-7495-7386)
- Soham Mitra (ORCID: https://orcid.org/0000-0002-4693-0006)
- Sharon L. Longo (ORCID: https://orcid.org/0009-0002-1967-9730)
- John A. Longo (ORCID: https://orcid.org/0009-0007-4827-0068)
Institutions
- SUNY Upstate Medical University (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0083
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00