Novel Thiazolidinedione Derivatives as Potential ZIKV Antiviral Inhibitors
Zika virus (ZIKV) remains a pressing global health concern due to its association with congenital Zika syndrome and the current lack of approved antiviral therapies. In this study, we evaluated the antiviral activity of three novel thiazolidinedione derivatives, GQ-402, GQ-396, and ZKC-10, against ZIKV in vitro and investigated their potential molecular targets through in silico analysis. GQ-402 exhibited the highest antiviral potency, with an IC<sub>50</sub> of 15.7 µM, while ZKC-10 achieved the most substantial reduction in viral RNA levels, as determined by RT-qPCR. Molecular docking studies identified GQ-396 as the top-ranked inhibitor of the NS2B-NS3 protease and NS5 RNA-dependent RNA polymerase, suggesting distinct mechanisms of action among the compounds. These findings highlight the therapeutic potential of thiazolidinedione derivatives and underscore the need for further investigation to develop effective treatments for ZIKV infection.
Authors
- Paulo André Teixeira de Moraes Gomes (ORCID: https://orcid.org/0000-0001-7089-5653)
- Moacyr Jesus Barreto de Melo Rêgo (ORCID: https://orcid.org/0000-0002-1883-6012)
- Marie‐Line Andréola (ORCID: https://orcid.org/0000-0001-9808-7391)
- Michelly Cristiny Pereira (ORCID: https://orcid.org/0000-0002-1672-8202)
- Marina Galdino da Rocha Pitta (ORCID: https://orcid.org/0000-0002-4219-2683)
- Sayonara Maria Calado Gonçalves (ORCID: https://orcid.org/0000-0001-7534-8448)
- José Arion da Silva Moura (ORCID: https://orcid.org/0000-0003-2700-1065)
- Douglas Carvalho Francisco Viana (ORCID: https://orcid.org/0000-0002-1133-8037)
- Floriane Lagadec (ORCID: https://orcid.org/0000-0001-9425-1190)
- Maíra Galdino da Rocha Pitta (ORCID: https://orcid.org/0000-0001-5881-0338)
- Mathieu Métifiot (ORCID: https://orcid.org/0000-0002-8103-9120)
- Michelle Melgarejo da Rosa (ORCID: https://orcid.org/0000-0002-0163-3833)
- Patrícia Recordon-Pinson (ORCID: https://orcid.org/0000-0001-6002-0941)
- Isabella Luiza Ralph de Oliveira
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Universidade Federal de Pernambuco (BR)
- Institut Polytechnique de Bordeaux (FR)
- Laboratoire de Microbiologie Fondamentale et Pathogénicité (FR)
Publication Details
- Journal
- Microorganisms
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3390/microorganisms13091967
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Financiadora de Estudos e Projetos
- Université de Bordeaux
- Universidade Federal de Pernambuco
- Universidade de Pernambuco