Identification of endothelial INSR as an osteosarcoma-related biomarker and therapeutic target based on weighted gene co-expression network analysis
INSR expression in OS tissues is associated with poor clinical outcomes. Activation or dysregulation of endothelial INSR contributes to OS progression, suggesting that endothelial INSR may represent a novel therapeutic target for OS.
Authors
- Zhifeng Zhou (ORCID: https://orcid.org/0000-0003-1716-3976)
- Jianfeng Jiang (ORCID: https://orcid.org/0000-0002-7625-0570)
- Yingkai Xu
- Lei Wang (ORCID: https://orcid.org/0009-0003-1667-099X)
- Zhiyong Hu (ORCID: https://orcid.org/0000-0002-9082-3056)
Institutions
- Nanjing University of Chinese Medicine (CN)
- Hainan Provincial Hospital of Traditional Chinese Medicine (CN)
- Anyang Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1007/s12672-025-03414-1
- Citations
- 1
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.80