The Investigation of Latanoprost's Effects on the Intraocular Pressure of Healthy Male guinea Pigs Under Light and Dark Regimes

The reduction in IOP caused by 0.005% latanoprost was more pronounced in guinea pigs kept in darkness compared to the animal exposed to light, suggesting that the diurnal and nocturnal patterns of IOP fluctuations are clinically significant in ocular hypertension therapy and, thus, should be considered when applying ophthalmic hypotensive agents. The study of IOP in guinea pigs provides valuable insights into circadian variations in IOP, which could help optimize treatment protocols by tailoring latanoprost administration to align with peak efficacy periods, potentially improving glaucoma management and therapeutic outcomes.