Real-time fMRI neurofeedback modulates auditory cortex activity and connectivity in schizophrenia patients with auditory hallucinations: A controlled study
Region-specific NFB targeting produces distinct neural changes beyond symptom reduction. STG-targeted NFB differentially modulates auditory-cognitive control networks, potentially restoring the disrupted balance between bottom-up sensory processing and top-down control in AHs. These findings highlight the importance of anatomically-informed NFB targets and provide mechanistic insights for developing precision interventions for treatment-resistant psychiatric symptoms.
Authors
- Kana Okano (ORCID: https://orcid.org/0000-0001-7289-9447)
- Melissa Hwang
- Yoon Ji Lee (ORCID: https://orcid.org/0000-0001-7295-5672)
- Paul Wighton (ORCID: https://orcid.org/0000-0002-6787-3856)
- Ann K. Shinn (ORCID: https://orcid.org/0000-0002-5311-6280)
- Angelina Awad
- Clemens Bauer (ORCID: https://orcid.org/0000-0002-3481-4438)
- Paul G. Nestor (ORCID: https://orcid.org/0000-0003-4890-8950)
- Francesca Morfini (ORCID: https://orcid.org/0000-0002-0330-6131)
- Lena Stone
- Jiahe Zhang (ORCID: https://orcid.org/0000-0002-7520-074X)
- Margaret Niznikiewicz (ORCID: https://orcid.org/0000-0003-3191-2005)
- Oliver Hinds
- Susan Whitfield‐Gabrieli (ORCID: https://orcid.org/0000-0002-9460-167X)
- Jude Hammoud
Institutions
- Northeastern University (US)
- Harvard University (US)
- McGovern Institute for Brain Research (US)
- McLean Hospital (US)
- VA Boston Healthcare System (US)
- Massachusetts General Hospital (US)
- Athinoula A. Martinos Center for Biomedical Imaging (US)
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Psychiatry Research Neuroimaging
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.pscychresns.2025.112050
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Institute of Mental Health