Inflammatory cytokine-primed MSC-derived extracellular vesicles ameliorate acute lung injury via enhanced immunomodulation and alveolar repair
Inflammatory cytokine priming substantially augments the immunomodulatory and tissue-regenerative efficacy of hADMSC-derived EVs, offering superior therapeutic effects in ALI models and promising activity against SARS-CoV-2-induced lung damage. These findings underscore the therapeutic potential of P-MEVs as an innovative, cell-free platform for treating severe pulmonary disorders, including ARDS.
Authors
- Ji-Suk Kim
- Daeha Seo (ORCID: https://orcid.org/0000-0002-0454-1168)
- Kyungmoo Yea (ORCID: https://orcid.org/0000-0002-3755-4520)
- Eunju Park (ORCID: https://orcid.org/0000-0002-3462-6090)
- Sungmin Kang (ORCID: https://orcid.org/0000-0002-4440-3544)
- Yongdeok Ahn (ORCID: https://orcid.org/0000-0002-0422-0487)
- Sanghee Shin (ORCID: https://orcid.org/0000-0002-8786-6995)
- Moon‐Chang Baek (ORCID: https://orcid.org/0000-0002-4266-1048)
- Jongwon Jeong (ORCID: https://orcid.org/0000-0003-0391-1929)
- Hanchae Cho (ORCID: https://orcid.org/0009-0007-3064-6549)
- Anyeseu Park
- Inseong Jung (ORCID: https://orcid.org/0000-0003-3528-2397)
- Ji-Won Shin (ORCID: https://orcid.org/0000-0002-7061-8055)
- Jun-Kook Park
- Soojeong Noh (ORCID: https://orcid.org/0000-0003-4275-9157)
- Hyun-Woo Kim (ORCID: https://orcid.org/0000-0003-1653-7737)
- Do‐Kyun Kim (ORCID: https://orcid.org/0000-0002-3457-4868)
- Jeong Yoon Lee
Institutions
- Daegu Gyeongbuk Institute of Science and Technology (KR)
- Kyungpook National University (KR)
- National University (SD)
- Jeonbuk National University (KR)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s13287-025-04576-z
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84