Exploration of a DDX3X Gene Supplementation Therapy Including Expanded Characterization and Novel Findings of Sleep Disturbances in Ddx3x Haploinsufficient Mice
While the gene therapy design used in this study was not effective, the data suggest that behavior can be modified by altering <i>Ddx3x</i> expression, warranting further exploration of gene therapy as a potential treatment approach. Additionally, the sleep disturbances present in <i>Ddx3x</i> <sup><i>+/-</i></sup> mutant mice phenocopy the reduced sleep quality seen in patients, further validating this model for research.
Authors
- Steven J. Gray (ORCID: https://orcid.org/0000-0002-6240-8621)
- Yuhui Hu (ORCID: https://orcid.org/0000-0002-5210-5301)
- Andrea Boitnott
- Erik J. Plautz (ORCID: https://orcid.org/0000-0001-8949-3064)
- Xin Chen (ORCID: https://orcid.org/0000-0003-0645-6319)
- Anjala Jiji
Institutions
- Southwestern Medical Center (US)
- Southwestern Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100599
- Primary Topic
- Genetics and Neurodevelopmental Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00