Relationship between 25(OH)D2, 25(OH)D3 and core symptoms in autism spectrum disorder
The levels of 25(OH)D<sub>2</sub> and 25(OH)D<sub>3</sub> in ASD children were significantly lower than those in healthy children. Besides, the study identified distinct roles for vitamin D isoforms including 25(OH)D<sub>2</sub> and 25(OH)D<sub>3</sub> in ASD pathophysiology. 25(OH)D<sub>2</sub> showed selective impairments in adaptive behavior and personal-social behavior. 25(OH)D<sub>3</sub> exhibited strong inverse correlations with symptom severity and positive associations with adaptive/fine motor/personal-social.
Authors
- Jia Liu (ORCID: https://orcid.org/0000-0003-0990-9299)
- Hongfei Du
- Zhao Deyun
Institutions
- Hospital of Hebei Province (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fped.2025.1622439
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00