Better off without you? - Attachment avoidance is linked to dissociative brain structural and functional patterns in patients with major depressive disorder and healthy controls
The results suggest that attachment avoidance is linked to distinct neuronal patterns in HC and MDD patients at the structural level and in reactivity to negative emotional stimuli located in regions associated with emotion perception and social cognition. The findings could be cautiously interpreted as neuronal correlates of hyper-, respectively hyposensitivity to socio-emotional cues and skill deficits in MDD patients, which could be specifically addressed in psychotherapy.
Authors
- Ronny Redlich (ORCID: https://orcid.org/0000-0002-7018-4525)
- Janine Selle
- Marie Uhlig (ORCID: https://orcid.org/0000-0002-8236-673X)
- Alexander Gussew (ORCID: https://orcid.org/0000-0003-2300-4883)
- Esther Zwiky (ORCID: https://orcid.org/0000-0002-6733-8087)
- Lara Fleischer
- Julie Hamann (ORCID: https://orcid.org/0009-0007-6205-3967)
- Andreas Deistung (ORCID: https://orcid.org/0000-0002-2427-1302)
- Konrad Schöniger (ORCID: https://orcid.org/0000-0002-1849-9490)
- Antonia Küttner (ORCID: https://orcid.org/0009-0001-6364-4896)
- Philine König (ORCID: https://orcid.org/0000-0002-5410-5444)
- Walter Alexander Wohlgemuth (ORCID: https://orcid.org/0000-0002-8076-6000)
- Robin Kamrla (ORCID: https://orcid.org/0000-0001-5163-9590)
- Julia Andreev (ORCID: https://orcid.org/0009-0008-0698-8079)
- Gina Sophie Scheiwe (ORCID: https://orcid.org/0009-0000-3316-0631)
Institutions
- German Center for Lung Research (DE)
- University Hospital in Halle (DE)
- Martin Luther University Halle-Wittenberg (DE)
Publication Details
- Journal
- Journal of Affective Disorders
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.jad.2025.120124
- Primary Topic
- Psychosomatic Disorders and Their Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00