Efficacy of an intranasally administered live attenuated PRRSV-2 vaccine against challenge with a highly virulent PRRSV-1 strain
The IN vaccine demonstrated non-inferiority to IM vaccination in alleviating clinical signs and helped reduce weight losses, however, at later times control of viral replication was lower, underscoring limitations in heterologous protection. The dissociation between systemic immune markers and tissue-specific outcomes highlights the need for strategies targeting tissue-resident immunity. These findings advocate further exploration of mucosal vaccination as a complementary strategy for PRRSV control, particularly under heterologous challenge conditions, while emphasizing the persistent challenges posed by viral diversity and incomplete cross-protection.
Authors
- Bernardo Lozano-Dubernard (ORCID: https://orcid.org/0009-0009-6430-7080)
- L. Aguirre (ORCID: https://orcid.org/0000-0002-1660-4031)
- Iván Díaz (ORCID: https://orcid.org/0000-0002-8090-1073)
- Marga Martı́n (ORCID: https://orcid.org/0000-0003-4370-6700)
- Martı́ Cortey (ORCID: https://orcid.org/0000-0003-1126-3423)
- David Sarfati-Mizrahi (ORCID: https://orcid.org/0009-0002-6558-6316)
- Jesús Horacio Lara-Puente
- José María Sánchez‐Carvajal (ORCID: https://orcid.org/0000-0003-0852-3765)
- Enric Mateu (ORCID: https://orcid.org/0000-0003-2715-6032)
- Irene Rodríguez‐Gómez (ORCID: https://orcid.org/0000-0002-1622-7109)
- Mònica Alberch
- María Soledad Serena (ORCID: https://orcid.org/0000-0001-5909-8098)
- I. Domingo-Carreño
- C. Artigas-Cabre
Institutions
- Universitat Autònoma de Barcelona (ES)
- Universidad Autónoma de la Ciudad de México (MX)
- Centre de Recerca en Sanitat Animal (ES)
- University of Córdoba (ES)
Publication Details
- Journal
- Frontiers in Veterinary Science
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fvets.2025.1619052
- Citations
- 2
- Primary Topic
- Animal Virus Infections Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.39