Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro
Compared to the intact 3DSE, this 3DWoundSE demonstrated enhanced responsiveness to injury and cytotoxic stimuli, confirming its utility for early wound response assessment. This platform offers a reproducible and ethically sound alternative to animal models, with potential applications in dermatological research, drug development, and therapeutic screening.
Authors
- Rima Nuwayhid (ORCID: https://orcid.org/0000-0001-7587-1968)
- Olga Kurow (ORCID: https://orcid.org/0000-0001-9831-0194)
- Dmitry Notov (ORCID: https://orcid.org/0009-0007-1826-5196)
- Nguyen Ngoc-Huyen (ORCID: https://orcid.org/0009-0009-4986-8314)
- Stefan Langer
Institutions
- University Hospital Leipzig (DE)
- 108 Military Central Hospital (VN)
Publication Details
- Journal
- Frontiers in Bioengineering and Biotechnology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.3389/fbioe.2025.1621566
- Citations
- 2
- Primary Topic
- Wound Healing and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Universität Leipzig
- Medizinische Fakultät, Universität Leipzig