Utilizing T1-weighted MRI intensity indices to evaluate in-vivo neurotoxicity in a South African cohort with environmental manganese exposure
Our findings suggest T1-weighted PI is associated with clinical neurotoxicity in environmental Mn exposure. This association is amplified by regular consumption of alcohol.
Authors
- Jason Lenox-Krug
- Jay R. Turner (ORCID: https://orcid.org/0000-0001-7787-6244)
- Brad A. Racette (ORCID: https://orcid.org/0000-0002-9582-8235)
- Wendy W. Dlamini (ORCID: https://orcid.org/0000-0002-7923-9115)
- Jordan Killion (ORCID: https://orcid.org/0000-0003-3155-1107)
- Gill Nelson (ORCID: https://orcid.org/0000-0001-7815-3718)
- Joshua S. Shimony (ORCID: https://orcid.org/0000-0002-6228-776X)
- Susan R. Criswell (ORCID: https://orcid.org/0000-0001-8467-371X)
- Irene Faust (ORCID: https://orcid.org/0000-0003-2653-672X)
- Susan Searles Nielsen (ORCID: https://orcid.org/0000-0001-7768-4736)
- Thomas E. Hutson (ORCID: https://orcid.org/0000-0002-4529-4212)
Institutions
- Barrow Neurological Institute (US)
- University of the Witwatersrand (ZA)
- University of Washington (US)
- Washington University in St. Louis (US)
- Mallinckrodt (United States) (US)
Publication Details
- Journal
- Journal of Trace Elements in Medicine and Biology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.jtemb.2025.127732
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Parkinson Disease Association
- National Institutes of Health