Exploring the presence of the GPR126 single nucleotide polymorphism (rs536714306) in periodontal patients of European ancestry
No variants (rs536714306) in the GPR126 gene were detected in any of the samples. The homozygous for the reference allele GG genotype was observed in 100% of participants across all groups examined. Absence of GPR126 [c.3086 G > A] polymorphism indicates no association with susceptibility to periodontitis in a Greek cohort and periodontally compromised cases of European ancestry. This is the first focused report evaluating the presence of this polymorphism in periodontitis patients in a European population. Further genome-wide studies in larger sample and diverse populations are warranted to fully elucidate the potential role of GPR126 polymorphisms in periodontal disease susceptibility.
Authors
- Galinos Fanourakis (ORCID: https://orcid.org/0000-0003-3866-0429)
- Heleni Vastardis (ORCID: https://orcid.org/0000-0001-5331-9355)
- Ioulia Chatzistamou (ORCID: https://orcid.org/0000-0002-6632-8469)
- Xanthippi Dereka (ORCID: https://orcid.org/0000-0002-9142-8613)
- Eirini Chatzopoulou (ORCID: https://orcid.org/0000-0002-8538-0182)
- Nikolaos Papanikolaou (ORCID: https://orcid.org/0000-0002-1028-1016)
Institutions
- University of South Carolina (US)
- National and Kapodistrian University of Athens (GR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Hôpital Rothschild (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Science and Technology Park of Crete (GR)
Publication Details
- Journal
- BMC Research Notes
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s13104-025-07443-5
- Citations
- 1
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- National and Kapodistrian University of Athens