Clinical Outcomes and Prognostic Factors of Vagus Nerve Stimulation in Drug-Resistant Epilepsy: A Single-Center Retrospective Cohort Study
Our findings demonstrate the sustained efficacy of VNS in managing DRE, with nearly half of the patients achieving clinically meaningful seizure control. The observed inverse association between disease duration and treatment response highlights the potential benefits of earlier VNS intervention. Together with its favorable safety profile, these results support the role of VNS as an integral component of comprehensive epilepsy management.
Authors
- Penghu Wei (ORCID: https://orcid.org/0000-0002-4529-7691)
- Zhiyuan Guan (ORCID: https://orcid.org/0000-0003-3977-8998)
- Guoguang Zhao (ORCID: https://orcid.org/0000-0002-7569-5252)
- Yongzhi Shan (ORCID: https://orcid.org/0000-0001-5510-1026)
- Jianwei Shi (ORCID: https://orcid.org/0009-0005-5842-7570)
- Hengxin Dong
- Tianren Wang
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- World Neurosurgery
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.wneu.2025.124408
- Primary Topic
- Vagus Nerve Stimulation Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Beijing Municipality
- Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support
- Beijing Municipal Science and Technology Commission
- Capital Health Research and Development of Special Fund