The Glycaemia Outcomes of Metformin with Add-on Vildagliptin or Sitagliptin in T2 Diabetes Mellitus

Introduction: T2DM is a global health concern requiring effective glycaemia management to reduce complications. While DPP-4 inhibitors like vildagliptin and sitagliptin are widely used with metformin, limited studies have compared their efficacy in lowering plasma glucose levels. This study aims to address this gap by evaluating the effectiveness of these combinations in glycemic control. Methods: A comparative observational study on 172 Patients with T2DM (≥30 years) was done with comorbidities like hypertension, dyslipidaemia, and obesity. Inclusion required lab data (FBG, PLBS, HbA1c, Cr, TG) and consent, while exclusions included T1DM, gestational diabetes, insulin therapy, alcohol use, and emergencies. Primary (HbA1c) and secondary (Cr, TG) outcomes were assessed. Results and Conclusion: The study showed that adding vildagliptin or sitagliptin to metformin significantly improved glycaemia control in T2DM Over six months. Both combinations effectively reduced FBS, PLBS, HbA1c, and TG without affecting renal function. In this cohort, patients receiving vildagliptin + metformin demonstrated a greater reduction in blood glucose levels compared to those receiving sitagliptin + metformin.