Gut microbial metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity decline through modulation of GSK-3β activity
These results indicate that TMAO can induce hippocampal-dependent learning and memory ability impairment with deficits in synaptic plasticity by regulating the GSK-3β activity.
Authors
- Yachen Shi (ORCID: https://orcid.org/0000-0003-2241-9227)
- Jingyu Deng (ORCID: https://orcid.org/0000-0003-4299-1327)
- Guangjun Xi
- Pan Wang (ORCID: https://orcid.org/0000-0003-3301-3177)
- Hui Wang (ORCID: https://orcid.org/0000-0003-4196-997X)
- Li Yang (ORCID: https://orcid.org/0000-0003-4961-0646)
- YangQuan Chen (ORCID: https://orcid.org/0000-0002-7422-5988)
- Feng Wang (ORCID: https://orcid.org/0009-0003-8660-9123)
- Xiangming Fang (ORCID: https://orcid.org/0000-0002-8818-5382)
- Yan Han (ORCID: https://orcid.org/0000-0002-6704-8477)
- Jiaojie Hui
Institutions
- Wuxi No.2 People's Hospital (CN)
- Wuxi People's Hospital (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1186/s13195-025-01846-z
- Citations
- 5
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.89
Funders
- University of Southern California
- Government of Jiangsu Province