Association of melatonin, green propolis and paclitaxel promotes inhibition of Ehrlich tumors in mice

Objective: To evaluate the antitumor action of Green Propolis and Melatonin. Methods: Ehrlich carcinoma cells were implanted in the subcutaneous tissue of male Swiss Webster mice, which were divided into experimental groups: Control, Animals that received 2 mg/kg of Melatonin; Animals treated with 50 mg/Kg of Propolis Verde; Animals treated with 5 mg/Kg of Paclitaxel; Animals treated with Melatonin and Green Propolis; Animals treated with Melatonin and Paclitaxel; Animals treated with Green Propolis and Paclitaxel; and Animals treated with Melatonin, Propolis Verde and Paclitaxel. Results: All protocols containing Green Propolis prevented metastatic and degenerative lesions in the lung and liver, minimizing the side effects of multidrug therapy. Although under the conditions applied in this study, Melatonin was not efficient in inhibiting EST, it attenuated myocarditis, renal tubular necrosis and pulmonary metastasis. Conclusion: Treatment with Melatonin, Propolis Verde and Paclitaxel showed the best results in reducing tumor weight, mitotic index and tumor inhibition, reinforcing the effectiveness of the association of natural compounds with chemotherapy in reducing tissue histopathological changes.