SYNTHESIS AND EVALUATION OF PRODRUG OF NSAIDS FOR REDUCTION OF ULCEROGENECITY

The ester prodrugs are for enhancing the anti-inflammatory activity and for reduction of ulcerogenic effects of NSAIDs. Also, the studies attempted to evaluate the pharmacokinetics of the prodrugs by in-vitro methods. The inflammation induced by carrageenan that is an acute model. The carriers used in research work, sesamol, umbelliferone and thymol, also produced anti-inflammatory activity and antioxidant effects. Therefore, overall, the synthesized products showed synergistic anti-inflammatory activity. The natural phenolic antioxidants for synthesizing the ester prodrugs are sesamol, 4- methyl umbelliferone and thymol and that itself showed various pharmacological activities. Keywords: NSAIDs, prodrug, antioxidants, umbelliferone, analgesic activity, anti-inflammatory activity