Nonketotic hyperglycemic hemichorea: white shadows on CT and T1-weighted MRI

Nonketotic hyperglycemic hemichorea (NHH) is a rare movement disorder, most commonly observed in elderly female patients with poorly controlled diabetes. We describe a 55-year-old male patient with diabetes who was admitted due to involuntary movements of the right limbs for five days. CT revealed a hyperdense lesion in the left putamen and caudate nucleus, while MRI showed hyperintensity on T1WI and hypointensity on both T2WI and diffusion-weighted imaging. The patient was treated with oral haloperidol and insulin for blood glucose control, leading to gradual symptom improvement. Follow-up imaging showed resolution of the lesions, correlating with clinical improvement. NHH has characteristic imaging findings and should be differentiated from cerebral hemorrhage, basal ganglia calcification, and hepatic encephalopathy.

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Publication Details

Journal
Journal of Radiation Research and Applied Sciences
Published
2025-08-22
DOI
https://doi.org/10.1016/j.jrras.2025.101890
Primary Topic
Neurological and metabolic disorders
Type
article
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article

Nonketotic hyperglycemic hemichorea: white shadows on CT and T1-weighted MRI

Libin Liu, Jiezhong Deng, Wenxiao Zhang, Juan‐juan Peng et al.
Journal of Radiation Research and Applied Sciences
Neurological and metabolic disorders
article

Nonketotic hyperglycemic hemichorea: white shadows on CT and T1-weighted MRI

Libin Liu, Jiezhong Deng, Wenxiao Zhang, Juan‐juan Peng, Zhihui Zhou
article en

Abstract

Nonketotic hyperglycemic hemichorea (NHH) is a rare movement disorder, most commonly observed in elderly female patients with poorly controlled diabetes. We describe a 55-year-old male patient with diabetes who was admitted due to involuntary movements of the right limbs for five days. CT revealed a hyperdense lesion in the left putamen and caudate nucleus, while MRI showed hyperintensity on T1WI and hypointensity on both T2WI and diffusion-weighted imaging. The patient was treated with oral haloperidol and insulin for blood glucose control, leading to gradual symptom improvement. Follow-up imaging showed resolution of the lesions, correlating with clinical improvement. NHH has characteristic imaging findings and should be differentiated from cerebral hemorrhage, basal ganglia calcification, and hepatic encephalopathy.

Journal of Radiation Research and Applied SciencesVol. 18(4)
Zhuhai People's Hospital (CN)
Zero hunger
Openalex Percentile: Top 70%
Neurological and metabolic disorders
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