Endothelin-2 from Keratinocytes and its Association with Itch in Skin Diseases
In chronic skin diseases such as atopic dermatitis (AD) or prurigo nodularis (PN), interactions between keratinocytes, immune cells, and nerve endings exacerbate both epidermal damage and the sensation of pruritus. ET-1, encoded by EDN1 is a non-histaminergic itch mediator that induces dose-dependent scratching in BALB/c mice and a burning itch in humans upon intradermal injection (Katugampola et al., 2000, McQueen et al., 2007). Elevated ET-1 levels are associated with increased disease severity in AD and psoriasis (Bonifati et al., 1998, Tsybikov et al., 2015).
Authors
- Bo Duan
- Mrinal K. Sarkar (ORCID: https://orcid.org/0000-0001-8505-4259)
- Mehrnaz Gharaee‐Kermani (ORCID: https://orcid.org/0000-0002-2177-2427)
- Matthew T. Patrick (ORCID: https://orcid.org/0000-0002-6174-9002)
- Lam C. Tsoi (ORCID: https://orcid.org/0000-0003-1627-5722)
- Johann Eli Gudjonsson (ORCID: https://orcid.org/0000-0002-0080-0812)
- J.M. Kahlenberg
- Xianying Xing (ORCID: https://orcid.org/0000-0003-4227-6868)
- Valérie Julia (ORCID: https://orcid.org/0000-0001-7813-1826)
- Stephan Weidinger (ORCID: https://orcid.org/0000-0003-3944-252X)
- Yuntian Wu (ORCID: https://orcid.org/0000-0002-3694-0817)
- Yumeng Dong (ORCID: https://orcid.org/0000-0001-9190-5902)
Institutions
- Central South University (CN)
- University of Michigan (US)
- University Hospital Schleswig-Holstein (DE)
- Michigan Medicine (US)
- Galderma (Switzerland) (CH)
- University of Lübeck (DE)
Publication Details
- Journal
- Journal of Investigative Dermatology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.jid.2025.07.030
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00