Kukoamine A from the root bark of Lycium chinense Miller enhances mobility in an aged Caenorhabditis elegans model by regulating mitochondrial function through HSF-1-mediated upregulation of heat shock proteins
KA treatment mitigated age-related locomotor decline by enhancing mitochondrial health and inducing HSF-1-mediated HSP activation across multiple cellular compartments.
Authors
- Chul Young Kim (ORCID: https://orcid.org/0000-0002-6988-1059)
- P. Ho
- Keunwan Park (ORCID: https://orcid.org/0000-0002-8783-9495)
- SoHyun Lee (ORCID: https://orcid.org/0000-0001-9992-6038)
- Uyen Tran Tu Nguyen (ORCID: https://orcid.org/0000-0002-7973-7528)
- Kyungsu Kang (ORCID: https://orcid.org/0000-0003-3846-7936)
- Won‐Young Bae (ORCID: https://orcid.org/0000-0002-6615-2547)
- Esther Youn (ORCID: https://orcid.org/0000-0001-7470-9387)
- Ji Hoon Kim (ORCID: https://orcid.org/0000-0002-2576-7502)
- Son Hung Tran (ORCID: https://orcid.org/0000-0002-3276-2611)
Institutions
- Hanyang University (KR)
- Korea Institute of Science and Technology (KR)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.jep.2025.120469
- Citations
- 1
- Primary Topic
- Genetics, Aging, and Longevity in Model Organisms
- Type
- article
- Field-Weighted Citation Impact
- 0.95
Funders
- Korea Institute of Science and Technology