Effects of Shared and Nonshared Schizophrenia and Bipolar Disorder Alleles on Cognition and Educational Attainment in the UK Biobank
Shared liability for SZ and BD is enriched for alleles that confer risk for poorer cognitive function in the general population but is associated with noncognitive traits that enhance EA. In contrast, SZ<sub>diff</sub> is enriched for alleles that confer risk for poorer EA through both cognitive and noncognitive mechanisms, which has implications for interventions. The enrichment of the differentiating fraction for HES genes in early and mid-adulthood and in the dentate gyrus highlights developmental stages and cell types important for future research.
Authors
- Nicholas J. Bray (ORCID: https://orcid.org/0000-0002-4357-574X)
- James Walters (ORCID: https://orcid.org/0000-0002-6980-4053)
- Nicholas E. Clifton (ORCID: https://orcid.org/0000-0003-2597-5253)
- Darren Cameron (ORCID: https://orcid.org/0000-0001-7520-7741)
- Michael John Owen (ORCID: https://orcid.org/0000-0003-4798-0862)
- Peter Holmans (ORCID: https://orcid.org/0000-0003-0870-9412)
- Eilidh Fenner (ORCID: https://orcid.org/0000-0002-6946-5768)
- Sophie E. Legge (ORCID: https://orcid.org/0000-0001-6617-0289)
- Michael O’Donovan (ORCID: https://orcid.org/0000-0001-7073-2379)
- Alexander Richards (ORCID: https://orcid.org/0000-0003-3218-7247)
- Claire Tume
Institutions
- University of Exeter (GB)
- Cardiff University (GB)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100601
- Citations
- 2
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 3.63