Anti-inflammatory activity of Stichopus variegatus from Onogate capsule to treat joint pain

Nonsteroidal anti-inflammation drugs (NSAIDs) are usually used to treat over-reaction of inflammatory reactions. However, the medicines have many side effects. On the other hand, a marine product like sea cucumbers (Stichopus variegatus) have to treat joint pain. This study aims to examine the anti-inflammatory effect of Stichopus variegatus extract powder from Onogate capsule produced by PT Nuswantara Nirmala Nusantara to treat joint pain. The research study employed 24 male white Wistar rats separated into six distinct categories: carrageenan control group, positive control group, healthy or normal group, group of S. variegatus extract test preparations at doses of 200 and 400 mg/Kg BW, and diclofenac Na as standard medicine. Microbial contamination was measured by total plate count (TPC) and total mold and yeast count (TMC). All data were analyzed using ANOVA with a significance level of p