Ticagrelor-induced acute isolated thrombocytopenia

Ticagrelor is an oral antiplatelet drug. The most common ticagrelor side effects include bleeding, dyspnea, bradycardia and in rare cases, microangiopathic hemolytic anemia. Isolated thrombocytopenia followed by a single-bolus dosage of ticagrelor is extremely uncommon. We encountered a 68-year-old male who had experienced rapid onset of chest pain and sweating for a day. The initial cardiac assessment suggested acute coronary syndrome and other laboratory tests, including a hemogram, were normal. The patient developed severe thrombocytopenia after receiving a loading dose of ticagrelor, despite the fact that no other thrombocytopenia-causing medicines were given to him. After discontinuing ticagrelor, the patient's platelet count gradually recovered with no need for additional transfusions or unnecessary investigations.