Incidence of laboratory-defined severe intravascular haemolysis across commercially available pulsed field ablation technologies for atrial fibrillation

Although over 17% of the cohort met the haematologic definition for significant IH, the absence of clinically significant renal impairment suggests that this threshold may not accurately reflect clinically meaningful haemolysis following PFA. The absence of clinical predictors or laboratory surrogates suggests that the rare risk of renal injury must be balanced with the well-established benefits of PFA when lesions are delivered in moderation optimizing tissue contact.