Navigating the Genetic Frontier: Establishing Genetic Clinics for Comprehensive Hereditary Cancer Management in Resource-Limited Settings
Abstract This review article explores the vital role of genetic clinics in the management of hereditary cancers, emphasizing their significance in early detection, tailored treatment, and family screening. It presents analysis of the prevalence of hereditary cancers in India, including breast, ovarian, prostate, colon, and kidney cancers, stressing the necessity for effective genetic testing and counseling services. The manuscript synthesizes available prevalence data, outlines key components and challenges of clinic establishment, and provides strategies for improving public acceptance, access, and workforce capacity. It also focuses on importance of early detection, family screening, and targeted therapies for patients with inherited genetic mutation. In conclusion, the article emphasizes the need for a patient-centered approach, increased access to genetic clinics, exploration of future genomics and technology advancements, and the evaluation of genetic clinics' impact on patient outcomes. By addressing challenges and capitalizing on opportunities, genetic clinics can continue to improve patients' and their families' lives, ultimately contributing to the battle against hereditary cancers.
Authors
- Archi Rungta
- Shashikant Patne (ORCID: https://orcid.org/0000-0002-1275-7444)
- Ankita Kapoor (ORCID: https://orcid.org/0000-0002-6600-6726)
- Bipinesh Sansar (ORCID: https://orcid.org/0000-0002-7656-8650)
- Rajiv Sarin (ORCID: https://orcid.org/0000-0002-6405-8282)
- Akhil Kapoor (ORCID: https://orcid.org/0000-0001-6006-2631)
- Bal Krishna Mishra (ORCID: https://orcid.org/0009-0007-1838-7097)
- Zachariah Chowdhury (ORCID: https://orcid.org/0000-0002-1766-5012)
- Satyajit Pradhan (ORCID: https://orcid.org/0000-0003-0376-6418)
- Amit Kumar (ORCID: https://orcid.org/0000-0001-5920-0048)
- Anuj Gupta (ORCID: https://orcid.org/0000-0002-1241-5436)
Institutions
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
Publication Details
- Journal
- Indian Journal of Medical and Paediatric Oncology
- Published
- 2025-08-22
- DOI
- https://doi.org/10.1055/s-0045-1811249
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00